Tampilkan postingan dengan label Teknik Biomedis. Tampilkan semua postingan
Tampilkan postingan dengan label Teknik Biomedis. Tampilkan semua postingan

Kamis, 18 November 2010

Teknik Biomedis

BENG 100: Frontiers of Biomedical Engineering 

 

Lecture 8 - Cell Communication and Immunology (cont.)






Overview:

 

Professor Saltzman continues his discussion of cell communication in the body, extending the description to the nervous and immune system. Professor Saltzman describes the mode of signal transmission in neurons: action potential in the axon, and neurotransmitter release at the synaptic cleft. He also introduces elements of the innate and adaptive immune system. The adaptive immune system is presented as a host/foreign antigen recognition system involving immune cells (T, B, and macrophages), antibodies, and the major histocompatibility complex 1 and 2. Immune response by cytotoxic T cells, T helper cells, and B cells to antigen recognition are discussed in detail.

Reading assignment:

Biomedical Engineering: Bridging Medicine and Technology,
in preparation by Mark Saltzman (forthcoming by Cambridge University Press); chapter 6



Summary and Key Concepts: Chapter 6 [PDF]

Resources:

 

 

Problem Set 4 [PDF]


References:


1. http://en.wikipedia.org/wiki/Immune_system
2. http://oyc.yale.edu/biomedical-engineering/beng-100

Minggu, 10 Oktober 2010

Teknik Biomedis

BENG 100: Frontiers of Biomedical Engineering 

 

 

Lecture 7 - Cell Communication and Immunology










Overview:

 

 

 

Professor Saltzman talks about cell communication, specifically ligand-receptor interactions that are important in maintaining homeostasis in the body. Different types of receptors and ligands, the nature of their interactions and ways to apply this into developing drugs are discussed (eg. Aldopa, Taximofen, beta-blockers). Next, Professor Saltzman talks about kinases, phosphatases, cyclic AMP and the mechanism of switching protein states. Three categories of cell communication signals are introduced: autocrine, paracrine, and endocrine. Finally, an example of cell communication using regulation/response to blood sugar level is presented.



Reading assignment:

 

 

 

Biomedical Engineering: Bridging Medicine and Technology,




in preparation by Mark Saltzman (forthcoming by Cambridge University Press); chapter 6
Summary and Key Concepts: Chapter 6 [PDF]


 

Class lecture:

 

 

http://oyc.yale.edu/biomedical-engineering/beng-100/lecture-7

 

 

References:



1. http://en.wikipedia.org/wiki/Immune_system
2. http://oyc.yale.edu/biomedical-engineering/beng-100


Rabu, 18 Agustus 2010

Prof. W. Mark Saltzman, Ph.D.


W. Mark Saltzman


Goizueta Foundation Professor of Biomedical Engineering & Chemical & Environmental Engineering

About Professor W. Mark Saltzman,Ph.D.



W. Mark Saltzman is the Goizueta Foundation Professor of Chemical and Biomedical Engineering at Yale University. His books include Drug Delivery: Engineering Principles for Drug Therapy and Tissue Engineering: Engineering Principles for the Design of Replacement Organs and Tissues, and his articles have appeared in Biomaterials and Nature Materials. The chair of the Department of Biomedical Engineering, Professor Saltzman is also the recipient of numerous distinguished teaching awards from Yale, Johns Hopkins, Cornell, and the University of Pennsylvania.


Ph.D., Harvard/MIT Division of Health Science and Technology

S.M., Massachusetts Institute of Technology

B.S., Iowa State University

RESPONSIBILITIES

Chair, Department of Biomedical Engineering

INTERESTS


Saltzman's research is motivated by the desire to create safer and more effective medical and surgical therapy. He focuses on tissue engineering and on creating better methods for drug delivery. His group has developed technology based on the use of bio-compatible polymeric materials for the controlled delivery of drugs, proteins, and genes. They have also developed new polymeric materials that influence the growth and assembly of tissues. However, even better than treating disease is to prevent disease from occurring in the first place. Saltzman's intent, therefore, is to develop the most economical, transportable, and accessible methods for disease prevention.

Saltzman is also committed to training a new generation of chemical and biomedical engineers. He believes in providing a stimulating and collaborative environment that promotes the free exchange of ideas and encourages creative blending of technology and modern biological science.

AWARDS & HONORS

  • Distinguished Lecturer Award, Biomedical Engineering Society (2004)
  • BP Amoco/H.Laurence Fuller Chair in Chemical Engineering at Cornell (2001)
  • Britton Chance Distinguished Lecturer in Engineering and Medicine, at the University of Pennsylvania (2000)
  • Professional Progress in Engineering Award from Iowa State University (2000)
  • Member, Surgery & Bioengineering Study Section (NIH) (1999)
  • Richard Tucker Excellence in Teaching Award (Cornell) (1999)
  • Fellow, American Institute of Biological and Medical Engineers (1997)
  • Controlled Release Society Young Investigator Award (1996)
  • Allan C. Davis Medal as Maryland's Outstanding Young Engineer (1995)
  • Distinguished Faculty Award for Excellence in Undergraduate Education (Johns Hopkins) (1995)
  • Camille and Henry Dreyfus Foundation Teacher-Scholar Award. (1990)

BOOKS

  • Drug Delivery: Engineering Principles for Drug Therapy, 2001, Published by Oxford University Press.
  • Tissue Engineering: Engineering principles for the design of replacement organs and tissues, 2004, Published by Oxford University Press.

REPRESENTATIVE PUBLICATIONS

  • Fibronectin terminated multilayer films: protein adsorption and cell attachment studies, C.R. Wittmer, J.A. Phelps, W. Mark Saltzman, Paul Van Tassel, 2007, Biomaterials, 28, 851.
  • Sustained target presentation in biodegradable polymers by surface modification with fatty acid conjugates , Tarek Fahmy, R.M. Samstein, C. Harness, W. Mark Saltzman, 2005, Biomaterials, 26, 5727-36.
  • Surface-mediated gene transfer from nanocomposites of controlled texture , H. Shen, J. Tan, W. Mark Saltzman, 2004, Nature Materials, 3, 569-574.
  • Multiphoton Microscopy Guides Neurotrophin Modification with Poly(ethylene glycol) to Enhance Interstitial Diffusion, Mark A. Stroh, S. Ma, W. W. Webb, W. Mark Saltzman, 2004, Nature Materials, 3, 489-494.