SENEBIAN MEDICAL SCHOOL: Oktober 2010

Minggu, 10 Oktober 2010

Teknik Biomedis

BENG 100: Frontiers of Biomedical Engineering

Lecture 7 - Cell Communication and Immunology

Overview:

Professor Saltzman talks about cell communication, specifically ligand-receptor interactions that are important in maintaining homeostasis in the body. Different types of receptors and ligands, the nature of their interactions and ways to apply this into developing drugs are discussed (eg. Aldopa, Taximofen, beta-blockers). Next, Professor Saltzman talks about kinases, phosphatases, cyclic AMP and the mechanism of switching protein states. Three categories of cell communication signals are introduced: autocrine, paracrine, and endocrine. Finally, an example of cell communication using regulation/response to blood sugar level is presented.

Reading assignment:

Biomedical Engineering: Bridging Medicine and Technology,

in preparation by Mark Saltzman (forthcoming by Cambridge University Press); chapter 6

Summary and Key Concepts: Chapter 6 [PDF]

Class lecture:

http://oyc.yale.edu/biomedical-engineering/beng-100/lecture-7

References:

1. http://en.wikipedia.org/wiki/Immune_system
2. http://oyc.yale.edu/biomedical-engineering/beng-100

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Course Description This course will assess the relationships among sequence, structure, and function in complex biological networks as well as progress in realistic modeling of quantitative, comprehensive, functional genomics analyses. Exercises will include algorithmic, statistical, database, and simulation approaches and practical applications to medicine, biotechnology, drug discovery, and genetic engineering. Future opportunities and current limitations will be critically addressed. In addition to the regular lecture sessions, supplementary sections are scheduled to address issues related to Perl, Mathematica and biology.

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